A flexible model for the development and validation of multianalyte methods for the determination of migrants from food contact materials |
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| Lampi, E., Dessipri, E., Poulima, I. |
- Abstract:
- Several thousands of chemical substances which are used in the production of food contact materials and articles have the potential to migrate into foods. It needs high analytical experience, hard work and high level instrumentation to determine the level of their migration into foods or food simulants. Development of multi-analyte methods is necessary in order to cope with the huge number of chemical compounds which should be determined. Application for the official control necessitates validation for each combination of analyte/substrate/simulant/migration condition.
A very promising approach is based on the design and development of a structured flexible model for the establishment of modular analytical process which will incorporate the standard migration methods, different substrates in combination with various analytes and will include procedures for samples’ preparation and instrumental analysis. The model foresees the extension to additional migrating compounds and food substrates followed by the necessary minimum validation actions in order to achieve a reliable result at the shortest time. The philosophy of this approach focuses on the breakdown of the analytical process into fully documented individual, independent and clearly defined stages (modules) which can be combined together to give the appropriate analytical process according to the target analyte(s) and simulants or food substrates. The implementation of this model provides a continuously expanding measurement capability of the laboratory with simultaneous satisfaction of the requirements for reliable, traceable and comparable results.
This model is successfully applied to plastics’ starting substances and additives, focusing on incorporation of the analysis of new plasticizers like diethylhexyl terephthalate using GC-FID and GC-MS instrumentation. - Keywords:
- flexible, multianayte, food contact materials (FCM)
- Download:
- IMEKO-TC23-2017-018.pdf
- DOI:
- -
- Event details
- IMEKO TC:
- TC23
- Event name:
- 3rd IMEKOFOODS Conference
- Title:
Metrology Promoting Standardization and Harmonization in Food and Nutrition
- Place:
- Thessaloniki, GREECE
- Time:
- 01 October 2017 - 04 October 2017